DNA ploidy in oral cavity carcinomas, with special reference to prognosis

✍ Scribed by Dr. Maciej Tytor; Gunnar Franzén; Jan Olofsson

• Book ID: 102847666
• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 579 KB
• Volume: 11
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/hed.2880110312

✦ Synopsis

Single-cell DNA cytofluorometry was performed on paraffin-embedded tissue of 140 patients with squamous cell carcinomas of the oral cavity. Half of the tumors (71 of 140) were DNA nondiploid. Well-differentiated carcinomas were more often DNA diploid than moderately well-differentiated ones (P <0.001; chisquare). The aneuploid tumors responded better to preoperative radiotherapy than did the DNA diploid (P<O.OOl) and polyploid tumors (P<0.05; chi-square). Using the multivariate Cox's regression analysis multiploid type tumor, age of the patients and presence of lymph node metastases were the only significant factors influencing survival. DNA diploid tumors in stages I and I 1 had a better prognosis than DNA nondiploid (W0.01; Kaplan-Meier). The reverse was true for stages Ill and IV, where DNA nondiploid tumors had a better prognosis (W0.05; Kaplan-Meier). Tumor stages (P<O.OOl; Kaplan-Meier) and especially lymph node metastases (P<0.0005; Kaplan-Meier) were major prognostic factors. Tumor DNA ploidy may be a complement to clinical and morphologic parameters as a prognostic predictor in squamous cell carcinoma of the oral cavity. HEAD & NECK 11 ~257-263,1989