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DNA fingerprinting of renal cell carcinoma with special reference to tumor heterogeneity

✍ Scribed by Christer Mehle; Börje Ljungberg; Roger Stenling; Göran Roos

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
471 KB
Volume
6
Category
Article
ISSN
1045-2257

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✦ Synopsis

Genomic alterations in renal cell carcinoma were investigated by D N A fingerprinting using the simple repetitive oligonucleotide probe (CAC),. Nine of ten tumors showed somatic changes in the fingerprint pattern compared with constitutional DNA. The most consistent changes were deletions and/or decrease in intensity of a band. When using two or three samples from different parts within the tumor, up to three different cell clones could be detected. These results indicate that D N A fingerprinting analysis can be a useful technique for the study of genomic alterations and tumor heterogeneity in renal cell carcinoma. Genes

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