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DNA photocleavage by dicationic bisintercalants

✍ Scribed by Marı́a-José Fernández; Kathryn B Grant; Francisco Herraiz; Xia Yang; Antonio Lorente

Book ID
104231148
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
120 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of new dicationic bisintercalants containing phenazine or naphthalene as photosensitizers and 4,4%-bipyridinium as a linker is reported. Irradiation in the presence of 0.5 mM concentrations of the phenazine intercalants affords cleavage of plasmid DNA (at 22°C, pH 7.0) in good to excellent yields.

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