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Specific Recognition of Loop DNA by Dicationic Porphyrins

✍ Scribed by Xiao-Cheng Weng; Jing Huang; Song Wu; Li-Ge Ren; Li-Wei Weng; Shu-Gao Zhu; Xiang Zhou

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
222 KB
Volume
4
Category
Article
ISSN
1612-1872

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✦ Synopsis

Abstract

A series of dicationic porphyrins were found to specifically recognize loop structures of oligodeoxynucleotides, and to selectively oxidize guanine residues upon photo‐irradiation at micromolar concentrations. These compounds could, thus, be employed as promising structural probes for specific secondary DNA structures. The production of singlet oxygen (^1^O~2~) is responsible for the DNA‐modification profiles. Both UV‐titration and thermal‐melting experiments indicate that the strong affinity of the charged porphyrins towards DNA loops is responsible for these molecular‐recognition phenomena.

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