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DNA overstretched state: S-DNA form or force-induced melting?: Comment on “Biophysical characterization of DNA binding from single molecule force measurements” by Mark C. Williams et al.

✍ Scribed by Oleg Krichevsky

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
81 KB
Volume
7
Category
Article
ISSN
1571-0645

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Microscopic implications of competing pictures of DNA overstretching: Comment on “Biophysical characterization of DNA binding from single molecule force measurements” by Kathy R. Chaurasiya, Thayaparan Paramanathan, Micah J. McCauley and Mark C. Williams
✍ Stephen Whitelam 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 75 KB

This work is a valuable review of experiments that probe the interactions of small molecules and DNA under tension. However, I disagree with the review's premise (Sections 1.3 and 2.1) that overstretching of bare, torsionally unconstrained DNA consists solely of dehybridization of the molecule. Und