DNA stretching as a probe for nucleic acid interactions: Reply to Comments on “Biophysical characterization of DNA binding from single molecule force measurements” by Kathy R. Chaurasiya, Thayaparan Paramanathan, Micah J. McCauley, Mark C. Williams

Microscopic implications of competing pi

Microscopic implications of competing pictures of DNA overstretching: Comment on “Biophysical characterization of DNA binding from single molecule force measurements” by Kathy R. Chaurasiya, Thayaparan Paramanathan, Micah J. McCauley and Mark C. Williams

✍ Stephen Whitelam 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 75 KB

This work is a valuable review of experiments that probe the interactions of small molecules and DNA under tension. However, I disagree with the review's premise (Sections 1.3 and 2.1) that overstretching of bare, torsionally unconstrained DNA consists solely of dehybridization of the molecule. Und