## Abstract ## Background. Cancer testis antigens (CTAs) are Tβcellβdefined tumorβassociated antigens encoded by the genes and gene families such as MAGE, NYβESOβ1, and others. Their expression in a wide variety of malignant neoplasms but absence in all normal adult tissue except testicular germ c
DNA mismatch repair protein expression and microsatellite instability in primary mucosal melanomas of the head and neck
β Scribed by C Marani; E Alvino; S Caporali; M G Vigili; G Mancini; S Rahimi
- Book ID
- 108780327
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 867 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0309-0167
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Little is known about genomic alterations during development of the radial growth phase (RGP) of cutaneous malignant melanomas (CMMs). In this investigation polymerase chain reaction-based microsatellite assays were applied to analyze 13 RGP-CMMs with 18 microsatellite markers at six chromosomal reg
Our previous studies of lung cancer in chromate-exposed workers (chromate lung cancer) have revealed that the frequency of replication error (RER) in chromate lung cancer is very high. We examined whether the RER phenotype of chromate lung cancer is due to an abnormality of DNA mismatch repair prote
## Abstract ## Background Histologic diagnosis of mucosal melanoma of the head and neck is difficult, requiring immunohistochemical stains which are less reliable than in cutaneous lesions. PNLβ2 is a novel marker that has not been examined in mucosal melanoma. ## Methods Nine formalinβfixed tis