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DNA Length-Dependent Cooperative Interactions in the Binding of Ku to DNA †

✍ Scribed by Ma, Yunmei; Lieber, Michael R.


Book ID
126464846
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
116 KB
Volume
40
Category
Article
ISSN
0006-2960

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✍ ALEXANDER TAGHVA; YUNMEI MA; MICHAEL R. LIEBER 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 253 KB

The loading of Ku onto a DNA end in a double-strand DNA break is thought to be one of the "rst steps in the non-homologous DNA end joining (NHEJ) pathway, giving it an essential role in the maintenance of genomic integrity. The binding of Ku to DNA is complicated since DNA can accommodate multiple K