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DNA hypermethylation leads to lower FOXP3 expression in CD4+ T cells of patients with primary Sjögren's syndrome

✍ Scribed by Yu, Xinhai; Liang, Gongping; Yin, Heng; Ngalamika, Owen; Li, Fen; Zhao, Ming; Lu, Qianjin


Book ID
120823735
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
382 KB
Volume
148
Category
Article
ISSN
1090-2341

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We studied the expression and function of 2 cell surface markers that induce T cell activation, CD3 and CD5, in 19 patients with primary Sjogren's syndrome (SS). The expression of CD3+ lymphocytes was normal, but CD3 function was moderately reduced, as measured by anti-CD3-induced T cell proliferati