✦ LIBER ✦

The expression and function of CD3 and CD5 in patients with primary sjögren's syndrome

✍ Scribed by Michael J. Dauphinée; Zair Tovar; Ana Ballester; Norman Talal

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 959 KB
Volume: 32
Category: Article
ISSN: 0004-3591
DOI: 10.1002/anr.1780320411

No coin nor oath required. For personal study only.

✦ Synopsis

We studied the expression and function of 2 cell surface markers that induce T cell activation, CD3 and CD5, in 19 patients with primary Sjogren's syndrome (SS). The expression of CD3+ lymphocytes was normal, but CD3 function was moderately reduced, as measured by anti-CD3-induced T cell proliferation. Anti-CD3induced stimulation of T cell help for Ig production and non-major histocompatibility complex-restricted (natural) killing were normal. In contrast, there was reduced expression and function of the CD5 molecule on peripheral blood lymphocytes of the SS patients. The ratio of CD5+ to CD3+ lymphocytes was 0.45 in SS patients compared with 0.85 in normal subjects, indicating that the CD3+ cells are relatively CD5-deficient in SS patients. Anti-CD5 monoclonal antibody did not augment suboptimal anti-CD3 stimulation of whole peripheral blood lymphocytes or of purified T lymphocytes from SS patients, which indicated impaired functioning of the CD5 molecule. A significant impairment in proliferation was found in response to phorbol myristate acetate and to ionomycin in combination, suggesting

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