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DNA-hydrolyzing activity of the light chain of IgG antibodies from milk of healthy human mothers

โœ Scribed by Tat'yana G Kanyshkova; Dmitry V Semenov; Denis Yu Khlimankov; Valentina N Buneva; Georgy A Nevinsky

Book ID
117108253
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
479 KB
Volume
416
Category
Article
ISSN
0014-5793

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## Abstract We present the first evidence demonstrating that small fractions of IgGs of all four subclasses (IgG1โ€“IgG4) are catalytically active in the hydrolysis of DNA and on average their relative activity (nM supercoiled DNA/1mg IgG/1โ€‰h) increases in the order: IgG1 (0.58)โ€‰<โ€‰IgG2 (0.94)โ€‰<โ€‰IgG3