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DNA Damage Response During Mitosis Induces Cancer Chromosomal Instability

✍ Scribed by Bakhoum, S.; Zaki, B.; Compton, D.; Kabeche, L.

Book ID
127168171
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
50 KB
Volume
90
Category
Article
ISSN
0360-3016

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## Abstract ## Background PhiC31 integrase facilitates efficient integration of transgenes into human and mouse genomes and is considered for clinical gene therapy. However recent studies have shown that the enzyme can induce various chromosomal abnormalities in primary human embryonic cells and m