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BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer

✍ Scribed by Rekha Rai; Hui Dai; Asha S. Multani; Kaiyi Li; Koei Chin; Joe Gray; John P. Lahad; Jiyong Liang; Gordon B. Mills; Funda Meric-Bernstam; Shiaw-Yih Lin

Book ID: 113523695
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 881 KB
Volume: 10
Category: Article
ISSN: 1535-6108
DOI: 10.1016/j.ccr.2006.07.002

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## Abstract The p53‐induced serine/threonine phosphatase, protein phosphatase 1D magnesium‐dependent, delta isoform (PPM1D) (or wild‐type p53‐induced phosphatase 1 (Wip1)), exhibits oncogenic activity in vitro and in vivo. It behaves as an oncogene in rodent fibroblast transformation assays and is