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DNA damage response and tumorigenesis in Mcm2-deficient mice

โœ Scribed by Kunnev, D; Rusiniak, M E; Kudla, A; Freeland, A; Cady, G K; Pruitt, S C


Book ID
109972334
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
789 KB
Volume
29
Category
Article
ISSN
0950-9232

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## Abstract Mice with disrupted germline __p53__ alleles have been engineered by us and others and have been shown to have enhanced susceptibility to spontaneous tumors of various types. We monitored a large number of __p53__โ€deficient mice(__p53__+/โˆ’ and __p53__โˆ’/โˆ’) and their wildโ€type littermates