## Abstract Acrolein (Acr) is a ubiquitous environmental contaminant; it also can be generated endogenously by lipid peroxidation. Acr contains a carbonyl group and an olefinic double bond; it can react with many cellular molecules including amino acids, proteins and nucleic acids. In this review a
DNA damage and mutagenicity induced by endosulfan and its metabolites
β Scribed by Mahima Bajpayee; Alok Kumar Pandey; Sabina Zaidi; Javed Musarrat; Devendra Parmar; Neeraj Mathur; Prahlad Kishore Seth; Alok Dhawan
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 275 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0893-6692
- DOI
- 10.1002/em.20255
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Certain chromium (Cr) compounds are known to be carcinogenic in humans and mutagenic in cell culture. However, the mechanism of Cr mutagenesis is not well understood. It appears that intracellular reduction of Cr by agents such as glutathione plays a role in the induction of DNA damage. We have used
The cytotoxicity of benzene (BZ) and its major metabolites phenol (PHE), hydroquinone (HQ), catechol (CAT), 1,4-benzoquinone (BQ), 1,2,4-benzenetriol (BT), truns,trans-muconic acid (ttMA) and S-phenylmercapturic acid (S-PMA) was assessed by exposing Chinese Hamster Ovary (CHO) cells to these compoun