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DNA Damage and Decreased DNA Repair in Peripheral Blood Mononuclear Cells in Individuals Exposed to Arsenic and Lead in a Mining Site

✍ Scribed by Yolanda Jasso-Pineda; Fernando Díaz-Barriga; Jaqueline Calderón; Leticia Yáñez; Leticia Carrizales; Iván N. Pérez-Maldonado

Book ID
113092850
Publisher
Humana Press Inc
Year
2011
Tongue
English
Weight
229 KB
Volume
146
Category
Article
ISSN
0163-4984

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## Abstract Arsenic is well established as a human carcinogen, but its precise mechanism of action remains unknown. Arsenic does not directly damage DNA, but may act as a carcinogen through inhibition of DNA repair mechanisms, leading indirectly to increased mutations from other DNA damaging agents