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DNA cross-linking in mammalian cells by pyrrolizidine alkaloids: Structure-activity relationships

โœ Scribed by Jeffrey R. Hincks; Hea-Young Kim; H.J. Segall; Russell J. Molyneux; Frank R. Stermitz; Roger A. Coulombe Jr.

Book ID
113207626
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
678 KB
Volume
111
Category
Article
ISSN
0041-008X

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โœ Jeffrey R. Hincks; Roger A. Coulombe Jr. ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 616 KB

Alkaline elution is a sensitive and commonly used technique to detect cellular DNA damage in the form of DNA strand breaks and DNA cross-links. Conventional alkaline elution procedures have extensive equipment requirements and are tedious to perform. Our laboratory recently presented a rapid, simpli