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DNA cleavage characteristics of non-protein enediyne antibiotic N1999A2

✍ Scribed by Naoko Miyagawa; Daisuke Sasaki; Mieko Matsuoka; Miki Imanishi; Toshihiko Ando; Yukio Sugiura


Book ID
117054021
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
286 KB
Volume
306
Category
Article
ISSN
0006-291X

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The present NMR and X-ray structural studies demonstrated that the new antibiotic N1999A2 isolated from the broth filtrate of Streptomyces sp. AJ9493, possesses a novel 9-membered ring enediyne chromophore similar to neocarzinostatin, but is not chromoprotein. Of special interest is the fact that st

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