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A new non-protein enediyne antibiotic N1999A2: Unique enediyne chromophore similar to neocarzinostatin and DNA cleavage feature

✍ Scribed by Toshihiko Ando; Makoto Ishii; Takayuki Kajiura; Toshiyuki Kameyama; Kiyoshi Miwa; Yukio Sugiura

Book ID: 104259762
Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 205 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)01383-5

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✦ Synopsis

The present NMR and X-ray structural studies demonstrated that the new antibiotic N1999A2 isolated from the broth filtrate of Streptomyces sp. AJ9493, possesses a novel 9-membered ring enediyne chromophore similar to neocarzinostatin, but is not chromoprotein. Of special interest is the fact that stable NI999A2 exists as enediyne ehromophore alone as well as dynemicin A, esperamicin A 1 and calicheamicin "Yv The major difference between NI999A2 and neocarzinostatin chromophore is lack of the amino sugar in NI999A2. The antibiotic N1999A2 revealed more random DNA cutting profile than neocarzinostatin chromophore.

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