DNA-based immunization against hepatitis B surface antigen (HBsAg) in normal and HBsAg-transgenic mice
β Scribed by Heather L. Davis; Cynthia L. Brazolot Millan; Maryline Mancini; Michael J. McCluskie; Michelle Hadchouel; Lacrimioara Comanita; Pierre Tiollais; Robert G. Whalen; Marie-Louise Michel
- Book ID
- 117432438
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 602 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0264-410X
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One hundred sixty-three persons immunised against hepatitis B with a vaccine containing HBsAg either of adw or ayw subtype were examined for antibodies against the a, d, and y determinants of HBsAg. Sera were tested for antibodies against HBsAg adw and HBsAg ayw separately by a solid-phase radioimmu
Recent data suggest that genes involved in the control of (1) immune responses of humans to HBsAg and (2) the susceptibility to the development of chronic hepatitis B are linked to the major HLA histocompatibility complex. Studies on the genetic regulation of anti-HBs responses and on the possible a
## Abstract To study the gene expression profiles in dendritic cells (DCs) from a hepatitis B surface antigen (HBsAg) positive host, transcriptional analysis of bone marrow βderived DCs from a lineage of HBsAg transgenic mice (#59) was compared to DCs from normal mice. Among the immuneβrelated gene