DNA-Based Amplified Bioelectronic Detection and Coding of Proteins

✍ Scribed by Joseph Wang; Guodong Liu; Bernard Munge; Lin Lin; Qiyu Zhu

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 114 KB
• Volume: 43
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200453832

✦ Synopsis

As research moves into the area of proteomics, scientists are faced with the challenge of developing effective tools for identifying, quantitating, and characterizing proteins. [1,2] Such new methods for analyzing proteins have the potential to improve drug discovery as well as the diagnosis and understanding of various disease states. The transduction of protein recognition events is of considerable interest for meeting this goal. Most clinical diagnostic methods for detecting proteins are based on conventional enzyme immunoassays. [3,4] These and other antibody-based techniques hold great promise for designing microarrays for detecting multiple protein targets. [5, 6]