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DNA analysis in Turkish Duchenne/Becker muscular dystrophy families

✍ Scribed by Esra Battaloğlu; Milhan Telatar; Feza Deymeer; Piraye Serdaroğlu; Faik Kuseyri; Coşkun Özdemir; Memnune Apak; Ashhan Tolun

Book ID
104670015
Publisher
Springer
Year
1992
Tongue
English
Weight
428 KB
Volume
89
Category
Article
ISSN
0340-6717

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✦ Synopsis

The molecular genetics of Duchenne/Becker muscular dystrophy was investigated in 81 affected Turkish families. Deletions were detected by multiplex polymerase chain reaction assays and cDNA Southern analyses. The distribution of the deletions along the gene and their correlation to clinical phenotype were different from the studies reported on other populations. Moreover, DNA polymorphisms in mothers were determined using 8 DNA probes and three CA repeat sequences, and a high degree of informativeness was observed.

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