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DNA analysis by mass spectrometry—past, present and future

✍ Scribed by Jörg Tost; Ivo Glynne Gut

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
483 KB
Volume
41
Category
Article
ISSN
1076-5174

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✦ Synopsis

Abstract

The analysis of deoxyribose nucleic acid (DNA) by mass spectrometry (MS) has evolved to where it can be used to analyze most known types of DNA and ribose nucleic acid (RNA) situations. It can efficiently deal with the analysis of DNA polymorphisms, sequences, haplotypes, human leukocyte antigen (HLA) typing, DNA methylation and RNA expression. Implementations of MS for these forms of DNA analyses are reviewed. The use of DNA analysis by MS is compared with competing technologies. Finally, an overview is given of worthwhile applications where the know‐how gained so far could be used for future developments. Copyright © 2006 John Wiley & Sons, Ltd.

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