## Mutations in the Parkin (PARK2) and the DJ1 (PARK7) gene cause early-onset Parkinson disease (EOPD). We tested 75 Serbian EOPD patients for mutations in both genes by conventional mutational screening (SSCP/dHPLC/sequencing) to detect small sequence alterations and by gene dosage studies (quanti
DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease
β Scribed by Hedrich, K.; Djarmati, A.; Schafer, N.; Hering, R.; Wellenbrock, C.; Weiss, P. H.; Hilker, R.; Vieregge, P.; Ozelius, L. J.; Heutink, P.
- Book ID
- 115521601
- Publisher
- Lippincott Williams and Wilkins
- Year
- 2004
- Tongue
- English
- Weight
- 212 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0028-3878
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Mutations in the parkin gene have been identified as a common cause of autosomal recessive inherited Parkinson disease (PD) associated with early disease manifestation. However, based on linkage data, mutations in other genes contribute to the genetic heterogeneity of early-onset PD (EOPD). Recently
## Abstract Mutations in __LRRK2__ (__leucineβrich repeat kinase 2__) have been associated with autosomal dominant Parkinson's disease (PD) and cluster in several 3β² exons of the gene. The majority of mutations have been detected in lateβonset cases (age at onset >50 years). We screened 5 of the 51