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DJ-1 mediates paraquat-induced dopaminergic neuronal cell death

✍ Scribed by Hyun Joo Kwon; Jun Young Heo; Jung Hee Shim; Ji Hoon Park; Kang Sik Seo; Min Jeong Ryu; Jeong Su Han; Minho Shong; Jin H. Son; Gi Ryang Kweon


Book ID
116923758
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
837 KB
Volume
202
Category
Article
ISSN
0378-4274

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Neuronal injury is intricately linked to the activation of three distinct neuronal endonucleases. Since these endonucleases are exquisitely pH dependent, we investigated in primary rat hippocampal neurons the role of intracellular pH (pH i ) regulation during nitric oxide (NO)-induced toxicity. Neur