## Abstract Gene mapping for complex diseases is still a challenge in genetic studies. For familyβbased studies, the singleβlocus methods for detecting linkage and linkage disequilibrium (LD) one at a time may not capture the assumed interaction between multiple causal genes efficiently. We propose
Division of linkage disequilibrium between absolute linkage disequilibrium and linkage equilibrium
β Scribed by Shin-ichi Kuno
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 222 KB
- Volume
- 50
- Category
- Article
- ISSN
- 1435-232X
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Contributions to Group 17 of the Genetic Analysis Workshop 15 considered dense markers in linkage disequilibrium (LD) in the context of either linkage or association analysis. Three contributions reported on methods for modeling LD or selecting a subset of markers in linkage equilibrium to perform l
## Abstract Linkage disequilibrium (LD) in the human genome, often measured as pairwise correlation between adjacent markers, shows substantial spatial heterogeneity. Congruent with these results, studies have found that certain regions of the genome have far less haplotype diversity than expected
Linkage analysis and association studies, two major approaches for genetic studies of human diseases, are useful for mapping genes that are highly penetrant, but both use only part of the information that is available for mapping disease genes. Therefore, they provide limited utility when used alone