Diversity in the human T cell receptor beta chain
โ Scribed by Regina LaRocque; Mary Ann Robinson
- Book ID
- 116114389
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 1023 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0198-8859
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The nucleotide sequences of 11 variable gene segments coding for rabbit T-cell receptor beta (Tcrb-V) chains were determined by directly sequencing fragments amplified by the cassette-ligation mediated polymerase chain reaction (CLM-PCR) and by modified anchor PCR without the cloning procedure. The
Although individual TCRVBV gene segments exhibit limited polymorphism, human T-cell receptor beta (TCRB) haplotypes are characterized by multiple different combinations of allelic markers. This observation suggests that genetic recombination may have played a role in the generation of these haplotyp