Divergent synthesis of cytotoxic styryl lactones isolated from Polyalthia crassa. The first total synthesis of crassalactone B

✍ Scribed by Velimir Popsavin; Goran Benedeković; Mirjana Popsavin; Vesna Kojić; Gordana Bogdanović

• Book ID: 104097785
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 297 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.04.114

✦ Synopsis

The first total synthesis of (+)-crassalactone B (2) and a new syntheses of (+)-crassalactone C (3) has been achieved starting from D-glucose. The natural products 2 and 3 can be selectively accessed by changing the conditions for TBDPS cleavage in the final intermediate 16. The synthesized natural products were evaluated for their cytotoxic activity against a panel of human tumour cell lines.