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Divergent effects of phorbol esters and insulin on insulin-like growth factor binding protein-1 (IGFBP-1) production and mRNA in rat H4IIe hepatoma cells

โœ Scribed by T.G. Unterman; R.G. Lacson; J.J. Jentel; D.T. Oehler


Book ID
117054896
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
652 KB
Volume
182
Category
Article
ISSN
0006-291X

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A sensitive RIA was used to examine regulation of IGFBP-1 in H411E rat hepatoma cells. IGFBP-1 was stimulated up to tenfold by dexamethasone and corticosterone, and this stimulation was abolished by RU486. The effect of dexamethasone increased with time in culture. Phorbol 12-myristate 13-acetate (P