A novel DNA/protein complex interacts with the insulin-like growth factor binding protein-1 (IGFBP-1) insulin response sequence and is required for maximal effects of insulin and glucocorticoids on promoter function

Insulin-like growth factor binding prote

Insulin-like growth factor binding protein-5 (IGFBP-5) interacts with thrombospondin-1 to induce negative regulatory effects on IGF-I actions

✍ Anna M. Moralez; Laura A. Maile; Jane Clarke; Walker H. Busby Jr.; David R. Clem 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 173 KB

## Abstract Insulin‐like growth factor binding protein‐5 (IGFBP‐5) and thrombospondin‐1 (TS‐1) are both present in extracellular matrix (ECM). Both proteins have been shown to bind to one another with high affinity. The purpose of these studies was to determine how the interaction between IGFBP‐5 a