Divergent effects of peroxisome proliferator–activated receptor-γ ligands in human and mouse nonalcoholic steatohepatitis
✍ Scribed by Stephen H. Caldwell; Curtis K. Argo
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 62 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0270-9139
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Peroxisome proliferator-activated receptor gamma (PPARgamma) has been the focus of studies assessing its potential neuroprotective role. These studies have shown either neuroprotection or neurotoxicity by PPARgamma ligands. Comparison of these studies is complicated by the use of different PPARgamma
## Abstract Peroxisome‐proliferator activated receptor‐gamma (PPARγ) belongs to a family of nuclear receptors and acts as receptor for peroxisome‐proliferators, steroids, retinoic acids, and polyunsaturated fatty acids. Our study examined the transcript levels of peroxisome‐proliferator activated r
Abbreviations: HSC, hepatic stellate cells; ␣-SMA, ␣ smooth muscle actin; PDGF, platelet-derived growth factor; PPAR␥, peroxisome proliferator-activated receptor ␥; 9-cisRA, 9-cis retinoic acid; RXR, retinoic X receptor; 15d-PGJ 2 , 15-deoxy-⌬ 12,14 prostaglandin J 2 ; [ 3 H]TdR, [methyl-3 H]thymidi