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Divergent effects of bryostatin 1 and phorbol myristate acetate on cell cycle arrest and maturation in human myelomonocytic leukemia cells (U937)

✍ Scribed by Julie A. Vrana; Aida M. Saunders; Srikumar P. Chellappan; Steven Grant

Book ID
114428610
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
496 KB
Volume
63
Category
Article
ISSN
0301-4681

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To investigate the role of iron in hematopoiesis, we studied effects of iron deprivation on PMA-induced monocyte/macrophage differentiation in HL-60 cells. Iron deprivation induced by desferrioxamine (DF) blocked PMA-induced differentiation and induced S-phase arrest and apoptosis in up to 60% of ce