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Effects of exogenous agmatine in human leukemia HMC-1 and HL-60 cells on proliferation, polyamine metabolism and cell cycle

✍ Scribed by Britta Haenisch; Heinz Bönisch; Sven Cichon; Jean-Pierre Allam; Natalija Novak; Gerhard J. Molderings


Book ID
113773401
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
426 KB
Volume
35
Category
Article
ISSN
0145-2126

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Topoisomerase II (TopoII) is a Mg-dependent enzyme involved in topological modifications of DNA that are crucial to the regulation of cell proliferation and possibly differentiation. To investigate the role of Mg availability in the modulation of TopoII in whole cells, we studied enzyme activity and