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Diuretic bioactivity optimization of furosemide in rats

โœ Scribed by Bryan Laulicht; Anubhav Tripathi; Edith Mathiowitz


Book ID
116438494
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
587 KB
Volume
79
Category
Article
ISSN
0939-6411

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Furosemide was given to rats as five different i.v. bolus doses (2.5-100mg kg-I), or as an i.v. infusion to a steady-state concentration in plasma of 14pgml-'. The urinary furosemide excretion rate (AAe/At) and the diuretic effect (volume of urine) were measured. A parallel shift in the excretion-re