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A Quantitative Method of Evaluating the Diuretic Response to Furosemide in Rats

✍ Scribed by Ryohei Hori; Katsuhiko Okumura; Ken-ichi Inui; Takashi Shibata; Toshihiro Kikkoji; Akira Kamiya

Book ID
114421209
Publisher
Springer US
Year
1988
Tongue
English
Weight
778 KB
Volume
05
Category
Article
ISSN
0724-8741

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Acute tolerance development to the diure
Acute tolerance development to the diuretic effect of furosemide in the rat
✍ Dr. Margareta Hammarlund; Lennart K. Paalzow πŸ“‚ Article πŸ“… 1985 πŸ› John Wiley and Sons 🌐 English βš– 607 KB

Furosemide was given to rats as five different i.v. bolus doses (2.5-100mg kg-I), or as an i.v. infusion to a steady-state concentration in plasma of 14pgml-'. The urinary furosemide excretion rate (AAe/At) and the diuretic effect (volume of urine) were measured. A parallel shift in the excretion-re