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Disturbance of the Cell Cycle with Colchicine Enhances the Growth Advantage of Diethylnitrosamine-initiated Hepatocytes in Rats

✍ Scribed by Tsutsumi, Masahiro ;Ohashi, Kazuo ;Tsujiuchi, Toshifumi ;Kobayashi, Eisaku ;Kobitsu, Kunihiko ;Kitada, Hiromichi ;Majima, Toshimitu ;Okajima, Eijiro ;Endoh, Takehiro ;Hasegawa, Kiyohiko ;Mori, Toshio ;Konishi, Yoichi

Book ID: 108581146
Publisher: Wiley (Blackwell Publishing)
Year: 1996
Tongue: English
Weight: 295 KB
Volume: 87
Category: Article
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1996.tb00192.x

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## Abstract Colchicine inhibited the initiation of DNA synthesis by hepatocytes in vivo and by WI‐38 and C3H10T 1/2 cells in vitro. All three cell types were most sensitive to colchicine when it was administered at the time of, or shortly after, proliferative activation (by partial hepatectomy or m