## Abstract Pyrithiamineโinduced thiamine deficiency (TD) is a wellโestablished model of Wernicke's encephalopathy in which a glutamateโmediated excitotoxic mechanism may play an important role in determining selective vulnerability. In order to examine this possibility, cultured astrocytes were ex
Distribution of Glutamate Transporter GLAST in Membranes of Cultured Astrocytes in the Presence of Glutamate Transport Substrates and ATP
โ Scribed by Jae-Won Shin; Khoa T. D. Nguyen; David V. Pow; Toby Knight; Vlado Buljan; Maxwell R. Bennett; Vladimir J. Balcar
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 402 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0364-3190
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## Abstract Glutamate is the major excitatory transmitter in the CNS and plays distinct roles in a number of developmental events. Its extracellular concentration, which mediates these activities, is regulated by glutamate transporters in glial cells and neurons. In the present study, we have used