Distribution of erb-b2, erb-b3, and erb-b4 in the developing avian nervous system
✍ Scribed by J. R. Francoeur; P. M. Richardson; R. J. Dunn; Dr. S. Carbonetto
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 946 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0360-4012
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The neuregulin proteins (GGF/ARIA/NDF/Heregulin) are pleiotrophic growth and differentiation factors whose receptors, erb‐B2, erb‐B3, and erb‐B4, are members of the epidermal growth factor receptor family of receptor tyrosine kinases. With western blots, we have examined the developmental and regional distribution of these receptors within the brain and sciatic nerve of chick embryos. The receptors erb‐B2, erb‐B3, and erb‐B4 are development and spatially regulated within the nervous system. In addition, cultures enriched for neurons or glia indicate that erb‐B2 and erb‐B4 are found in both neurons and glia, whereas erb‐B3 is found in glia alone. © 1995 Wiley‐Liss, Inc.
📜 SIMILAR VOLUMES
## Background: Synovial sarcoma is a malignant mesenchymal tumor composed of varying proportions of spindle and epithelial cell components. because of the histologic and immunohistochemical similarity of synovial sarcoma to epithelial carcinomas, we hypothesized that the human epithelial growth fac
## Abstract The c‐__erb__ B‐2/__neu__ gene encodes a cell‐surface glycoprotein with extensive homology to, but distinct from, the epidermal growth‐factor receptor. In this study, we compared the c‐__erb__ B‐2/__neu__ gene amplification and expression of tissue specimens obtained from the bladders o
## Abstract Both amplification and overexpression of c‐__erb__ B‐2/__neu__ have been associated with the progression and possible prognosis of a number of human cancers. In this study, we demonstrated that c‐__erb__ B‐2/__neu__ may also play an important role in human prostate cancer. Our conclusio