## Abstract The c‐__myc__ proto‐oncogene was analyzed in 311 cases of primary breast cancer, in 8% of which it was found to be amplified, usually at moderately increased copy number (2‐5 copies). The adjacent pvt gene was co‐amplified with c‐__myc__ in all tumors analyzed. C‐__myc__ amplification w
Prognostic value of erb-B2 and myc amplification in breast cancer imprints
✍ Scribed by Ulf Lönn; Sigrid Lönn; Bo Nilsson; Björn Stenkvist
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 901 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0008-543X
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Amplification of the int-2 oncogene was measured in a series of breast tumours and related to amplification of the c-myc and c-erbB-2 oncogenes, histopathological features and relapse-free and overall survival. int-2 was amplified in I I%, c-myc in 20% and c-erbB-2 in 27% of the tumours assessed. in