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Distribution of concanavalin A receptors on normal rat liver cells and zajdela ascites hepatoma cells

✍ Scribed by J. Roth

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
727 KB
Volume
14
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The distribution of Concanavalin A receptors in cultures of normal rat liver cells and of Zajdela ascites hepatoma cells of the rat was investigated by the Con A‐po technique (Bernhard and Avrameas, 1971). Con A‐po labelling of the cell surface showed a patchy distribution of Concanavalin A receptors in ascites hepatoma cells, whereas continuous Con A‐po labelling was seen at the surface of normal rat liver cells. The different distribution of Concanavalin A receptors was caused by rapid internalization of Con A‐po labelled material and not by a simple rearrangement of the receptors. The significance of this process is discussed with respect to Concanavalin A receptor mobility and membrane stability after cell transformation.

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