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Distribution of cholesterol sulfate and its anabolic and catabolic enzymes in various rabbit tissues

✍ Scribed by Yongxi Cui; Masao Iwamori

Publisher
Springer-Verlag
Year
1997
Tongue
English
Weight
609 KB
Volume
32
Category
Article
ISSN
0024-4201

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## Abstract The enzyme specificity and tissue distribution of zenarestat, an aldose reductase inhibitor, was investigated in diabetic rats. Zenarestat inhibited both rat sciatic nerve aldose reductase (AR) activity and recombinant human AR with IC~50~ values of 7.5 and 44 nM, respectively. However,