✦ LIBER ✦

Distribution of carbamazepine and its epoxide in blood compartments in adolescent and adult epileptic patients

✍ Scribed by J. Bonneton; P. Genton; Dr E. Mesdjian

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 331 KB
Volume: 13
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510130604

No coin nor oath required. For personal study only.

✦ Synopsis

Carbamazepine (CBZ) used in the treatment of epilepsy, is metabolized in man to an active metabolite: carbamazepine 10-1 1 epoxide (CBZ-E). CBZ and CBZ-E concentrations in the different blood compartments (plasma ultrafiltrate, plasma proteins, and red blood cells (RBC)) of epileptic patients on CBZ monotherapy were assessed using HPLC. The highest CBZ and CBZ-E level to dose ratios were observed in the RBC. For CBZ and CBZ-E significant correlations were found between some blood compartments particularly between RBC and plasma ultrafiltrate. The measurement of CBZ and CBZ-E in all blood compartments may be interesting in uncontrolled patients and in patients presenting sideeffects which cannot be explained by total plasma concentration values.

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