✦ LIBER ✦

Distribution of 111 in-bleomycin complex in small cell lung cancer cells by autoradiography

✍ Scribed by De-Yan Hou; Yosh Maruyama

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 709 KB
Volume: 49
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930490206

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✦ Synopsis

The distribution of ' I 'In-bleomycin Complex ( I ' 'In-BLMC) in small cell lung cancer (SCLC) cells was studied by autoradiography. SCLC cells were exposed to "'In-BLMC and '' 'Indium chloride (" 'InCI,) for 1 hour, 3 hours, and 4 hours; washed with fresh medium; and spread on slides. The slides were smeared with NTB, (NTB,) emulsion by wet or dry-mount technique and exposed 3 to 15 days. "'In-BLMC was found to localize in the cell nucleus and nuclear membrane (78.3%); ' 'InCl, located mainly in the cytoplasm (52.3%). This distribution of labeled BLM may explain the mechanism of killing SCLC cells by ' "In-BLMC.

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