Distribution and stability of [111In]bleomycin and its fractions in tumor-bearing mice
β Scribed by De-Yan Hou; Hans Hoch; Gerald S. Johnston; K.C. Tsou; Raymond J. Farkas; Elizabeth E. Miller
- Book ID
- 116083913
- Publisher
- Elsevier Science
- Year
- 1984
- Weight
- 863 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0047-0740
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The pharmacokinetics of E7Ga-citrate, "'In-bleomycin, \*I-bleomycin, and \*Ifibrinogen were compared in a murine KHJJ tumor model in order to assess their relative potential as agents for in vivo detection of cancer. Although all four agents have been reported to be clinically efficacious, in this t
## Abstract We have found a new ^111^Inβbleomycin complex (BLMC), which has high affinity to tumor, does not bind to transferrin and is stable in vivo. Distribution in animals bearing glioma, hepatoma, or mammary adenocarcinoma at 48 hours showed: the ratios of tumor to blood, brain, heart, lung, l
Mice bearing transplanted glioma received 0.9% NaCl, 0.1 mg of BLM, or 200-250 pCi of "'In-BLM (0.1 mg BLM) daily for 5 days intraperitoneally. After therapy, tumor sizes were in the order NaCl > BLM > "'In-BLM. On the 11th day after the first injection, tumor size (m3) in the "'In-BLM group was 1,2