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A new tumor imaging agent-111In-bleomycin complex. Comparison with 67Ga-citrate and 57Co-Bleomycin in tumor-bearing animals

✍ Scribed by De-Yan Hou; Hans Hoch; Gerald S. Johnston; K. C. Tsou; Alfred E. Jones; Elizabeth E. Miller; Steven M. Larson

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
778 KB
Volume
27
Category
Article
ISSN
0022-4790

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✦ Synopsis

Abstract

We have found a new ^111^In‐bleomycin complex (BLMC), which has high affinity to tumor, does not bind to transferrin and is stable in vivo. Distribution in animals bearing glioma, hepatoma, or mammary adenocarcinoma at 48 hours showed: the ratios of tumor to blood, brain, heart, lung, liver, pancreas, stomach, and femur were 1.4‐22.4 times as high for ^111^In‐BLMC as for ^67^Ga‐citrate. In mammary adenocarcinoma, ^111^In‐BLMC bound more to viable and ^57^Co‐Bleomcyin (BLM) more to necrotic tumor. In viable tumor, the concentration of ^111^In‐BLMC was similar to that of ^57^Co‐BLM. The ratios of tumor to stomach and pancreas were higher, to blood, brain, muscle, heart, and femur were lower for ^111^In‐BLMC than those for ^57^Co‐BLM. The ratios of tumor to lung, liver, spleen, skin, and kidney were similar for the two compounds. Tumors were imaged more distinctly with the new ^111^In‐BLMC and ^57^Co‐BLM than with ^67^Ga‐citrate. ^111^In‐BLMC is promising for tumor imaging.

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