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Distribution and metabolism of doxorubicin in rats undergoing testicular circulatory isolation

โœ Scribed by Hirohumi Arakawa; Karl J. Mueller; William G. Doubek; John A. Stern; Marie C. La Regina; Kym C. Tolman; Carmine J. Coscia; Frank E. Johnson

Book ID
115695214
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
498 KB
Volume
162
Category
Article
ISSN
0002-9610

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Distribution of doxorubicin in rats unde
Distribution of doxorubicin in rats undergoing ultrasonic drug delivery
โœ Bryant J. Staples; William G. Pitt; Beverly L. Roeder; Ghaleb A. Husseini; Deept ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 141 KB

Ultrasound (US) increases efficacy of drugs delivered from micelles, but the pharmacokinetics have not been studied previously. In this study, US was used to deliver doxorubicin (Dox) sequestered in micelles in an in vivo rat model with bilateral leg tumors. One of two frequencies with identical mec