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Distribution and Excretion of Labelled 3,3-dimethyl-1-(3-methyl-aminopropyl)-1-phenylphtalane (Lu 3-010) in the Rat and Dog

✍ Scribed by Forshell, G. Plym


Book ID
114798519
Publisher
Wiley (Blackwell Publishing)
Year
2009
Weight
50 KB
Volume
25
Category
Article
ISSN
0001-6683

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The absorption and metabolic fate of 7-chloro-3,3adihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)( 1,3)-benzoxazin-9-one (I) was studied in rats, dogs, and humans. Orally administered I was readily absorbed by all species. In the rat, orally administered I was converted to its metabolite, 5-chlorosalicylic