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Distribution and Metabolism of 3,3-dimethyl-1-(3-methylaminopropyl)-1-phenyl-phthalane (Lu 3-010), a Bicyclic Compound with Thymoleptic Properties

✍ Scribed by Forshell, G. Plym ;Schauman, P. ;Hansen, V. ;Larsen, U. Dahl ;Jørgensen, A. ;Overø, K. Fredricson


Book ID
114798581
Publisher
Wiley (Blackwell Publishing)
Year
2009
Weight
944 KB
Volume
26
Category
Article
ISSN
0001-6683

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The arecoline bioisostere, Lu 25-109-T, displays a pharmacological profile of a partial muscarinic agonist with a several-fold higher affinity for cortical M 1 receptors than for brain stem M 2 receptors and salivary glands M 3 receptors. The compound is selective for muscarinic receptors as it show