Distinctive Multidrug Sensitivity and Outcome of Acute Erythroblastic and Megakaryoblastic Leukemia in Children With Down Syndrome
β Scribed by Sayuri Yamada; Teruaki Hongo; Shuichi Okada; Chieko Watanabe; Yuji Fujii; Hiroki Hori; Makoto Yazaki; Ryoji Hanada; Yasuo Horikoshi
- Publisher
- Carden Jennings Publishing
- Year
- 2001
- Tongue
- English
- Weight
- 94 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0925-5710
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Of 2947 children with acute lymphocytic leukemia (ALL), treated during three consecutive studies of the Pediatric Oncology Group (1974-1986), 52 (1.8%) had Down's Syndrome (DS). Comparison of clinical and laboratory characteristics showed no significant differences in leukocyte count, racial distrib
## Abstract Previous cytogenetic studies of myeloid and acute lymphoblastic leukemias in children with Down syndrome (MLβDS and DSβALL) have revealed significant differences in abnormality patterns between such cases and acute leukemias in general. Also, certain molecular genetic aberrations charac