Distinctive cerebellar immunoreactivity for the prion protein in familial (E200K) Creutzfeldt-Jakob disease
β Scribed by Christa Jarius; Gabor G. Kovacs; Girma Belay; Johannes A. Hainfellner; Eva Mitrova; Herbert Budka
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- English
- Weight
- 662 KB
- Volume
- 105
- Category
- Article
- ISSN
- 0001-6322
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π SIMILAR VOLUMES
Inherited prion diseases are characterized by mutations in the PRNP gene encoding the prion protein (PrP). As the other sporadic or infectious prion disease forms, they are almost all characterized by the accumulation in the brain of an abnormal misfolded form of the patient's PrP. Brain extracts ca
Creutzfeldt-Jakob disease (CJD) is a transmissible neurodegenerative disorder characterized by the accumulation of the amyloid protein PrP in the CNS. Two coding polymorphisms of the PrP gene (PRNP) are a methionine (Met) to valine (Val) change at codon 129, and a deletion in the octapeptide coding