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Distinctive cerebellar immunoreactivity for the prion protein in familial (E200K) Creutzfeldt-Jakob disease

✍ Scribed by Christa Jarius; Gabor G. Kovacs; Girma Belay; Johannes A. Hainfellner; Eva Mitrova; Herbert Budka


Publisher
Springer-Verlag
Year
2003
Tongue
English
Weight
662 KB
Volume
105
Category
Article
ISSN
0001-6322

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Creutzfeldt-Jakob disease (CJD) is a transmissible neurodegenerative disorder characterized by the accumulation of the amyloid protein PrP in the CNS. Two coding polymorphisms of the PrP gene (PRNP) are a methionine (Met) to valine (Val) change at codon 129, and a deletion in the octapeptide coding